Molecular Diversity of Microbes Lab

Selected publications

Shomar H*.,Georjon H.*, Feng Y, Olympio B, Cury J, Tesson F., Wu F*., Bernheim A*.
Viperin immunity evolved across the tree of life through serial innovations on a conserved scaffold
bioRxiv https://www.biorxiv.org/content/10.1101/2023.09.13.557418v1

Georjon H, Bernheim A.
The highly diverse antiphage defence systems of bacteria
Nature Reviews Microbiology, 1/-15 (2023)

Cury J.*,Mordret E*., Trejo-Hernandez V., Tesson F., Ofir G., Poirier Z. P., Bernheim A.
Conservation of antiviral systems across domains of life reveals novel immune mechanisms in humans
bioRxiv, https://doi.org/10.1101/2022.12.12.520048 (2022)

Tesson F., Hervé A., Touchon M., Mordret E., d’Humières C., Cury J., Bernheim A.
Systematic and quantitative view of the anti-viral arsenal of prokaryotes.
Nature Communications, 13:256 (2022)

Bernheim A., Millman A., Ofir G., Meitav G., Abraham C., Shomar H., Rosenberg M., Tal N., Melamed S., Amitai G., Sorek R.
Prokaryotic viperins produce diverse antiviral molecules.
Nature, 589, 120-124 (2021)

All publications

2023

Georjon H, Bernheim A.
The highly diverse antiphage defence systems of bacteria
Nature Reviews Microbiology, 1/-15 (2023)

Georjon H., Tesson F., Shomar H*., Bernheim A*.
Genomic characterization of the antiviral arsenal of Actinobacteria
Microbiology Aug;169(8):001374 (2023)

Tesson F., Bernheim A.
Synergy and regulation of antiphage systems: toward the existence of a bacterial immune system?.
Curr Opinion in Microbiology Feb:71:102238 (2023°

2022

Cury J, Bernheim A
CRISPR-Cas and restriction-modification team up to achieve long-term immunity
Trends in Microbiology S0966-842X(22)00091-9. (2022)

Millman A., Melamed S., Leavitt A., Doron S., Bernheim A, Hör J., Lopatina A., Ofir G., Hochhauser D., Stokar-Avihail A., Tal N., Sharir S., Voichek M., Erez Z., Lorenzo M Ferrer J., Dar D., Kacen A., Amitai G., Sorek R.
An expanding arsenal of immune systems that protect bacteria from phages
Cell Host and Microbes 30, 1556–1569 (2022)

Rousset F., Depardieu F., Miele S., Dowding J., Liebermann E., Garry D., Rocha E.P.C, Bernheim A, Bikard D.
Phages and their satellites encode hotspots of antiviral systems.
Cell Host and Microbes S1931-3128(22)00104-4 (2022)

Klompe S, Jaber N, Bel L, Mohabir J, Bernheim A, Sternberg S.
Evolutionary and mechanistic diversity of Type I-F CRISPR-associated transposons
Molecular Cell 82 (3), 616-628e5 (2022)

2021

Bernheim A., Millman A., Ofir G., Meitav G., Abraham C., Shomar H., Rosenberg M., Tal N., Melamed S., Amitai G., Sorek R.
Prokaryotic viperins produce diverse antiviral molecules.
Nature, 589, 120-124 (2021)

2020

Millman A*, Bernheim A*, Stokar-Avihail A.*, Fedorenko T., Voichek M., Leavitt A., Sorek R.
Bacterial retrons function in anti- phage defense
Cell, 183 (6), 1551-1561 (2020)

Bernheim A, Sorek R
The bacterial pan-immune system: anti-phage defense as a community resource
Nature Reviews Microbiology 18, 113–119 (2020)

Bernheim A, Bikard D, Touchon M, Rocha EPC:
Atypical organizations and epistatic interactions of CRISPRs and cas clusters in genomes and their mobile gemetic elements
Nucleic Acids Research 48 (2), 748-760 (2020)

Before 2020

Bernheim A, Bikard D, Touchon M, Rocha EPC
A matter of background: DNA repair, pathways as a possible cause for the sparse distribution of CRISPR–Cas, systems in bacteria.
Philosophical Transactions of the Royal Society B 374 (1772), 2018008 (2019)

Bernheim A, Calvo-Villaman A, Basier C, Cui L, Rocha EPC, Touchon M, Bikard D, Inhibition of NHEJ repair by type II-A CRISPR-Cas systems
Nature Communications 8 (1), 1-9 (2017)